ResearchSafe

1P-LSD (1-Propionyl-LSD)

Category: Psychedelics. Status: Schedule I (research compound).

A close chemical relative of LSD that the body appears to convert back into LSD, giving a near-identical experience. Widely used in research as a legal-gray-area LSD alternative in some regions.

How it works

Likely acts as a prodrug for LSD, activating serotonin 5-HT2A receptors.

Key facts

  • Molecular weight: 379.50 g/mol
  • Half-life: ~3-5 hours
  • Bioavailability: Oral
  • Storage: Research/reference only.

Dosing overview

  • Typical dose: Varies by individual and setting
  • Frequency: Occasional
  • Duration: Acute effects last 8-12 hours
  • Route: Oral

Protocol notes

  • Taken orally on blotter or as liquid, almost identical to LSD in use and duration.
  • People clear their day because effects last 8-12 hours.

Reported benefits

  • Nearly identical to LSD
  • Used as a research LSD analog
  • Long, classic psychedelic experience
  • Well-known harm-reduction profile

Possible side effects

  • Long, intense experiences
  • Anxiety or fear
  • Raised heart rate and blood pressure
  • Visual distortions for hours

Community reviews of 1P-LSD

Rated 3.7 out of 5 from 3 community reviews by ResearchSafe members.

  • rachel266 rated it 3/5 - Slight clarity boost but no lasting shift: Anecdotally, the only thing that mattered was a brief period of mental clarity during a long, wandering trip; it helped me organise thoughts about retirement plans for an hour, then faded. Beyond that, the experience felt typical and not particularly transformative.
  • night_dad rated it 4/5 - 1P‑LSD helped me break through a creative block at work: I was stuck on a stubborn data analysis problem for weeks, feeling flat after long lab shifts. After a low‑dose 1P‑LSD trip one Saturday, the visuals were mild but my mind felt unusually spacious. Ideas that had been looping finally clicked, and I mapped out a solution by the next morning. The experience was pleasant and safe, though the comedown left me a bit groggy for a few hours. Overall, it was helpful.
  • gains_mom264 rated it 4/5 - Mental break from the ICU stress: Tried this for eight weeks, helped me disconnect from work stress for sure. Seemed to clear my head, just my own experience. Felt like a beauty of a trip, almost identical to LSD. Only downside was the long duration, it's a commitment, eh. 4/5 stars.

Compare 1P-LSD

Research and educational reference only. Not medical advice.