Urolithin A Research Guide

Full name: Urolithin A (Mitophagy Activator)

A gut-microbiome metabolite of ellagitannins (found in pomegranates, walnuts, and berries) that many people cannot produce on their own. Studied for improving mitochondrial health and muscle function by triggering mitophagy.

How Urolithin A Works

Stimulates mitophagy - the selective recycling of damaged mitochondria - improving mitochondrial quality and energy efficiency in muscle and other tissues.

Dosing Protocol

• Typical dose: 500-1000 mg per day
• Frequency: Once daily
• Duration: Ongoing (8+ weeks for muscle effects)
• Route: Oral

Reported Benefits

• Improves mitochondrial function (mitophagy)
• Increased muscle endurance
• Cellular energy support
• Studied for healthy aging

Potential Side Effects

• Generally well tolerated
• Mild GI effects (uncommon)

Research Citations

1. Urolithin A improves muscle endurance (2022) - Randomized trial reported improved muscle endurance and mitochondrial biomarkers in middle-aged adults.
2. Urolithin A safety and mitophagy (2019) - First-in-human study showed it was safe and engaged mitochondrial gene expression.

Related Anti-Aging Compounds

• Epithalon - Full Profile
• NAD+ - Full Profile
• Humanin - Full Profile
• FOXO4-DRI - Full Profile
• SS-31 (Elamipretide) - Full Profile
• GDF-11 - Full Profile

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