SS-31 (Elamipretide) Research Guide

Full name: SS-31 / Elamipretide (Bendavia)

A mitochondria-targeted tetrapeptide concentrating 1000-5000x in inner mitochondrial membrane. Stabilizes cardiolipin and optimizes electron transport. In clinical trials for Barth syndrome and heart failure.

How SS-31 (Elamipretide) Works

Targets cardiolipin in inner mitochondrial membrane, stabilizes cytochrome c binding, optimizes electron transfer efficiency, and reduces mitochondrial ROS by 50%.

Dosing Protocol

• Typical dose: 5-40 mg
• Frequency: Daily
• Duration: 4-12 weeks
• Route: Subcutaneous or IV

Reported Benefits

• Mitochondrial function optimization
• Reduced oxidative stress
• Cardioprotection
• Improved exercise capacity
• Renal protection
• Cellular energy

Potential Side Effects

• Injection site reactions
• Headache
• Mild GI effects
• Taste disturbance (IV)

Research Citations

1. Elamipretide improves mitochondrial function in heart failure (2022) - Improved LV function, exercise capacity, and quality of life in HFrEF patients.
2. SS-31 reverses age-related mitochondrial dysfunction (2021) - Eight weeks restored coupling efficiency and reduced H2O2 emission by 50% in aged skeletal muscle.

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