Semax Research Guide

Full name: Semax (ACTH 4-10 analog)

A synthetic peptide from ACTH(4-10) with Pro-Gly-Pro stabilization. Approved in Russia for stroke and cognitive disorders. Enhances attention, memory, and neuroplasticity.

How Semax Works

Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity.

Dosing Protocol

• Typical dose: 200-600 mcg per dose
• Frequency: 2-3x daily
• Duration: 2-4 week courses
• Route: Intranasal drops/spray

Reported Benefits

• Enhanced attention/focus
• Memory improvement
• Neuroprotection (stroke)
• BDNF/NGF upregulation
• Improved learning
• Optic nerve support

Potential Side Effects

• Nasal irritation
• Headache
• Hair loss (very high doses, rare)
• Irritability

Research Citations

1. Semax neuroprotection in acute ischemic stroke (2021) - Intranasal semax within 6h of stroke reduced infarct volume by 25% and improved outcomes at 30 days.
2. Cognitive enhancement by semax in healthy volunteers (2020) - Improved working memory by 20% and selective attention by 30% in 14-day crossover study.

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