Dihexa Research Guide

Full name: Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide)

An angiotensin IV analog reported 10 million times more potent than BDNF at enhancing synaptic connectivity. Promotes synaptogenesis and spinogenesis.

How Dihexa Works

Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits.

Dosing Protocol

• Typical dose: 10-20 mg (oral) or 2-5 mg (SubQ)
• Frequency: Daily
• Duration: 4-8 weeks
• Route: Oral or Subcutaneous

Reported Benefits

• Dramatic synaptogenesis
• Memory improvement
• Cognitive restoration potential
• Dendritic spine growth
• HGF/c-Met activation

Potential Side Effects

• Limited safety data
• Theoretical cancer concern (c-Met)
• Headache
• Overstimulation

Research Citations

1. Dihexa as cognitive enhancer via HGF/c-Met (2019) - Restored scopolamine-impaired memory at picomolar concentrations through hippocampal synaptogenesis.
2. Angiotensin IV analogs augment hippocampal connectivity (2018) - Increased functional synaptic connections by 300% through c-Met dependent spinogenesis.

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