Rapamycin Research Guide

Full name: Rapamycin (Sirolimus)

An mTOR inhibitor originally used as an immunosuppressant, now the most studied pharmaceutical longevity compound. Low-dose pulsed rapamycin is prescribed by longevity telemedicine clinics for its anti-aging and immune-rejuvenating properties.

How Rapamycin Works

Inhibits mTOR complex 1 (mTORC1), reducing cellular growth signaling and activating autophagy - the cellular recycling process. Mimics caloric restriction at the molecular level.

Dosing Protocol

• Typical dose: 3-6 mg
• Frequency: Once weekly
• Duration: Ongoing (pulsed)
• Route: Oral tablet

Reported Benefits

• Enhanced autophagy
• Immune rejuvenation
• Anti-aging cellular effects
• Cancer risk reduction
• Improved vaccine response (elderly)
• Longevity extension

Potential Side Effects

• Mouth sores
• Impaired wound healing
• Elevated lipids
• Immunosuppression (at high doses)
• GI upset

Research Citations

1. Low-dose rapamycin in human aging (2023) - Weekly rapamycin improved immune function in elderly adults with 40% better vaccine response and no clinically significant immunosuppression.
2. mTOR inhibition and lifespan extension (2022) - Pulsed rapamycin extended median lifespan by 20-26% in multiple mammalian models across both sexes.

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