Progesterone Research Guide

Full name: Micronized Progesterone (Prometrium)

A bioidentical hormone with neuroprotective, sleep-promoting, and anti-estrogenic properties. Used in both male and female HRT protocols for mood stabilization, deep sleep enhancement, and estrogen balancing.

How Progesterone Works

Agonizes progesterone receptors and GABA-A receptors (via allopregnanolone metabolite). Inhibits 5-alpha reductase, opposes estrogen proliferative effects, and promotes myelination in neural tissue.

Dosing Protocol

• Typical dose: 100-200 mg oral or 20-40 mg topical
• Frequency: Nightly (oral) or daily (topical)
• Duration: Ongoing
• Route: Oral capsule, topical cream, or vaginal

Reported Benefits

• Enhanced deep sleep (GABA modulation)
• Neuroprotection
• Estrogen opposition
• Reduced anxiety
• DHT reduction (5AR inhibition)
• Cardiovascular protection

Potential Side Effects

• Drowsiness
• Mild dizziness
• Breast tenderness
• Mood changes (rare)
• Bloating

Research Citations

1. Progesterone and neuroprotection after TBI (2020) - Progesterone reduced neuronal cell death by 40% and improved cognitive outcomes in traumatic brain injury models.
2. Oral progesterone and sleep architecture (2019) - Micronized progesterone increased slow-wave sleep by 25% without next-day sedation, via allopregnanolone GABA modulation.

Related Hormone Replacement Compounds

• Gonadorelin - Full Profile
• Enclomiphene - Full Profile
• DHEA - Full Profile
• Pregnenolone - Full Profile
• Liothyronine (T3) - Full Profile
• Anastrozole - Full Profile

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