NMN Research Guide

Full name: Nicotinamide Mononucleotide

A direct precursor to NAD+, a coenzyme central to cellular energy production and DNA repair that declines with age. Supplemented to raise NAD+ levels and support mitochondrial function and metabolic health.

How NMN Works

NMN is converted to NAD+ via the NAD+ salvage pathway (through NMNAT enzymes). Higher NAD+ supports sirtuin activity, PARP-mediated DNA repair, and mitochondrial energy metabolism.

Dosing Protocol

• Typical dose: 250-1000 mg per day
• Frequency: Once daily
• Duration: Ongoing
• Route: Oral (capsule/sublingual)

Reported Benefits

• Raises cellular NAD+ levels
• Supports mitochondrial energy production
• Promotes DNA repair via sirtuins/PARPs
• Studied for metabolic and vascular health

Potential Side Effects

• Generally well tolerated
• Mild flushing or nausea (uncommon)
• GI upset at high doses
• Long-term human data still limited

Research Citations

1. NMN supplementation and metabolic health (2021) - Improved muscle insulin sensitivity in prediabetic women in a randomized trial.
2. Safety of oral NMN in healthy adults (2022) - Doses up to 900 mg/day raised blood NAD+ and were well tolerated.

Related Anti-Aging Compounds

• Epithalon - Full Profile
• NAD+ - Full Profile
• Humanin - Full Profile
• FOXO4-DRI - Full Profile
• SS-31 (Elamipretide) - Full Profile
• GDF-11 - Full Profile

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