ResearchSafe

CJC-1295 (CJC-1295 (Modified GRF 1-29))

Category: Growth Hormone. Status: Research compound.

A synthetic GHRH analog with 4 amino acid substitutions for stability. Often combined with DAC for extended half-life or used without DAC for pulsatile release.

How it works

Binds GHRH receptors on anterior pituitary somatotrophs, stimulating cAMP-dependent GH synthesis and pulsatile release.

Key facts

  • Molecular weight: 3,368 Da (without DAC)
  • Half-life: 30 minutes (no DAC) / 8 days (with DAC)
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.

Dosing overview

  • Typical dose: 100-300 mcg
  • Frequency: 1-3x daily (no-DAC)
  • Duration: 8-16 weeks
  • Route: Subcutaneous injection

Protocol notes

  • No-DAC (Mod GRF 1-29) is almost always paired with a GHRP (ipamorelin/GHRP-2) for a synergistic GH pulse.
  • Typical: 100 mcg CJC + 100-200 mcg ipamorelin, injected together.
  • Dose 1-3x daily: pre-bed is the highest-value pulse; pre-workout and fasted-morning are common adds.

Reported benefits

  • Increased GH production
  • Improved body composition
  • Enhanced recovery
  • Better sleep quality
  • Anti-aging effects
  • Fat loss

Possible side effects

  • Flushing
  • Headache
  • Water retention
  • Tingling/numbness
  • Increased hunger

Research

  • CJC-1295 effects on GH secretion in healthy adults (2020): Increased mean GH levels by 200-1000% and IGF-1 by 50-70% sustained over 6-14 days after single injection.
  • Pulsatile vs sustained GH release with GHRH analogs (2019): Non-DAC CJC-1295 preserved physiological GH pulsatility while achieving 2-10x baseline elevation.

Community reviews of CJC-1295

Rated 3.9 out of 5 from 15 community reviews by ResearchSafe members.

  • researcher465 rated it 5/5 - Better recovery than I got from GHRP-2 alone: I ran CJC-1295 for about 6 weeks while I was in Japan training through a heavy block and long recovery runs. For me it seemed to make mornings smoother, and my legs felt less flat after hard sessions. I had tried GHRP-2 before for the same recovery goal, and I preferred CJC-1295 because it felt steadier and a little more clean. Could be partly placebo, but the change was clear to me.
  • travis556 rated it 3/5 - decent recovery boost but not much else for me: i tried cjc-1295 mainly hoping it’d help my recovery between lifting sessions, and i did notice i wasn’t as sore and bounced back a bit quicker, but honestly that’s about it, nothing major changed for me, maybe it’s age or genetics, but for me it wasn’t earth-shaking.
  • sanjay_swims rated it 4/5 - steadier recovery over 3 months, with a small catch: i ran cjc-1295 for about 3 months while juggling software work in the uk and keeping my swim training moving. week 1, honestly, not much. by week 2 or 3 i started waking up a bit fresher, and my legs felt less cooked after hard sessions. month 2 was where it felt most noticeable, recovery between training blocks seemed smoother. by month 3 it was still helpful, though the sleep boost got a bit less obvious. i’d call it solid 4/5 for me.
  • chris_sleepnerd rated it 5/5 - Skeptical at first, but my sleep actually turned around: I went into CJC-1295 pretty skeptical, because I’ve seen a lot of hype float around peptides, and as a pharmacist by training I’m usually the guy asking for the actual numbers instead of the internet fairy dust. I ran it about 6 weeks, mostly because my sleep was getting wrecked from hospital shifts, early mornings, and still trying to lift here in the South heat. For me, the change showed up in deeper sleep and better recovery, and that seemed to spill over into mood and training the next day. I was honestly surprised, the skepticism did not stick around long. I’d give my own experience 5 ou
  • recovery_freya rated it 3/5 - Mild payoff, mostly in the sleep department: I ran CJC-1295 for about 3 months while juggling pharmacist shifts and training on the East Coast, hoping it would help me recover better and keep my sleep less garbage. For me, sleep got a little deeper and I woke up a bit less wrecked, but the body comp piece was pretty subtle, maybe just me being more on top of diet and training. Solid middle of the road, 3 stars, and yeah, I’d call that fair 🔥
  • peptidehead_katie rated it 4/5 - Better sleep, but morning glucose needed watching: I ran CJC-1295 for about 6 weeks while I was doing early shifts and trying to keep training steady. For me, it fit best on days when my routine was already boring and structured, which is most days in pharmacy life anyway. I noticed my sleep felt a bit deeper, and recovery after leg sessions seemed smoother, like I was not dragging as much the next morning. The caveat was my fasting glucose looked a touch less neat on my home checks, so I kept an eye on that. Overall, a solid 4 from me. Helpful, but I would still treat it carefully, na?

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Community discussions about CJC-1295

Research and educational reference only. Not medical advice.