Alprostadil Research Guide

Full name: Alprostadil (Prostaglandin E1)

A synthetic form of prostaglandin E1 used to treat erectile dysfunction by directly relaxing penile blood vessels. It works independently of sexual arousal and is delivered by injection or urethral suppository under medical guidance.

How Alprostadil Works

Alprostadil activates prostaglandin receptors that raise intracellular cAMP in cavernosal smooth muscle, causing vasodilation and increased blood inflow to produce an erection regardless of nerve signaling or arousal.

Dosing Protocol

• Typical dose: Provider-titrated per response
• Frequency: As needed before activity
• Duration: On demand
• Route: Intracavernosal injection or urethral pellet

Reported Benefits

• Effective for erectile dysfunction
• Works independent of arousal
• Rapid onset
• Useful when oral PDE5 inhibitors fail

Potential Side Effects

• Penile pain
• Prolonged erection/priapism
• Injection site bruising
• Dizziness
• Rare fibrosis with repeated use

Research Citations

1. Alprostadil for erectile dysfunction (2018) - Intracavernosal alprostadil produced reliable erections in a majority of men, including PDE5-inhibitor non-responders.

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