Kisspeptin-10 Research Guide

Full name: Kisspeptin-10 (Metastin 45-54)

The shortest bioactive kisspeptin fragment, a master regulator of reproduction. Activates GnRH neurons to stimulate the HPG axis, increasing LH, FSH, and sex hormones.

How Kisspeptin-10 Works

Binds KISS1R on GnRH neurons, stimulating GnRH pulsatile release for LH/FSH secretion. Also enhances limbic sexual arousal circuits.

Dosing Protocol

• Typical dose: 1-10 nmol/kg
• Frequency: Single dose or daily
• Duration: Acute or short-course
• Route: IV or Subcutaneous

Reported Benefits

• Stimulates GnRH naturally
• Increases LH and testosterone
• Enhances sexual arousal (fMRI data)
• Potential fertility aid
• HPG axis diagnostic tool

Potential Side Effects

• Hot flashes
• Headache
• Transient LH surge
• Nausea (rare)

Research Citations

1. Kisspeptin-10 and sexual brain processing in men (2022) - Increased limbic brain activity to sexual stimuli by 40% and improved penile tumescence.
2. Kisspeptin restores LH pulsatility in hypothalamic amenorrhea (2021) - Restored LH pulses in women with functional HA, suggesting fertility therapeutic potential.

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