Melanotan II vs TriMix
A side-by-side research comparison of Melanotan II and TriMix across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Melanotan II | TriMix |
|---|---|---|
| Full name | Melanotan II (MT-II) | TriMix (Papaverine + Phentolamine + Alprostadil) |
| Category | Sexual Health | Sexual Health |
| Status | Research compound | Compounded medication |
| Mechanism | Non-selective MCR agonist: MC1R produces tanning, MC3R/MC4R increase sexual arousal, MC4R suppresses appetite. Broader receptor activity than PT-141. | Papaverine relaxes smooth muscle via PDE inhibition. Phentolamine blocks alpha-adrenergic receptors. Alprostadil (PGE1) directly stimulates cAMP production in cavernosal tissue. Together they produce reliable penile erection independent of arousal. |
| Molecular weight | 1,024 Da | Combination compound |
| Half-life | 2-3 hours | ~1-3 hours (local effect) |
| Bioavailability | High (SubQ) | Direct intracavernosal: ~100% |
| Typical dose | 0.25-1 mg | 0.1-0.5 mL (titrated) |
| Frequency | Loading: daily/EOD · then 2x weekly maintenance | As needed, max 3x/week |
| Route | Subcutaneous injection | Intracavernosal injection |
Melanotan II reported benefits
- Skin tanning
- Enhanced sexual function
- Appetite suppression
- UV protection (melanin)
- Libido enhancement
TriMix reported benefits
- Reliable erectile response
- Works when oral meds fail
- Rapid onset (5-15 min)
- Adjustable dosing
- No systemic cardiovascular effects
Related comparisons
Research and educational reference only. Not medical advice.