Kisspeptin-10 vs Melanotan II
A side-by-side research comparison of Kisspeptin-10 and Melanotan II across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Kisspeptin-10 | Melanotan II |
|---|---|---|
| Full name | Kisspeptin-10 (Metastin 45-54) | Melanotan II (MT-II) |
| Category | Sexual Health | Sexual Health |
| Status | Research compound | Research compound |
| Mechanism | Binds KISS1R on GnRH neurons, stimulating GnRH pulsatile release for LH/FSH secretion. Also enhances limbic sexual arousal circuits. | Non-selective MCR agonist: MC1R produces tanning, MC3R/MC4R increase sexual arousal, MC4R suppresses appetite. Broader receptor activity than PT-141. |
| Molecular weight | 1,302 Da | 1,024 Da |
| Half-life | 4-6 min (IV) / 20-30 min (SubQ) | 2-3 hours |
| Bioavailability | High (IV/SubQ) | High (SubQ) |
| Typical dose | 1-10 nmol/kg | 0.25-1 mg |
| Frequency | Single dose or daily | Loading: daily/EOD · then 2x weekly maintenance |
| Route | IV or Subcutaneous | Subcutaneous injection |
Kisspeptin-10 reported benefits
- Stimulates GnRH naturally
- Increases LH and testosterone
- Enhances sexual arousal (fMRI data)
- Potential fertility aid
- HPG axis diagnostic tool
Melanotan II reported benefits
- Skin tanning
- Enhanced sexual function
- Appetite suppression
- UV protection (melanin)
- Libido enhancement
Related comparisons
Research and educational reference only. Not medical advice.