Melanotan II vs Oxytocin
A side-by-side research comparison of Melanotan II and Oxytocin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Melanotan II | Oxytocin |
|---|---|---|
| Full name | Melanotan II (MT-II) | Oxytocin (OXT) |
| Category | Sexual Health | Sexual Health |
| Status | Research compound | FDA Approved |
| Mechanism | Non-selective MCR agonist: MC1R produces tanning, MC3R/MC4R increase sexual arousal, MC4R suppresses appetite. Broader receptor activity than PT-141. | Binds OXTR in social cognition brain regions (amygdala, nucleus accumbens) and reproductive organs. Modulates serotonin and dopamine in reward circuits. |
| Molecular weight | 1,024 Da | 1,007 Da |
| Half-life | 2-3 hours | 3-5 min (IV) / 20-30 min (intranasal) |
| Bioavailability | High (SubQ) | Low (oral), Moderate (intranasal ~2-5%) |
| Typical dose | 0.25-1 mg | 20-40 IU intranasal |
| Frequency | Loading: daily/EOD · then 2x weekly maintenance | As needed or daily |
| Route | Subcutaneous injection | Intranasal or IV (obstetric) |
Melanotan II reported benefits
- Skin tanning
- Enhanced sexual function
- Appetite suppression
- UV protection (melanin)
- Libido enhancement
Oxytocin reported benefits
- Enhanced social bonding
- Improved intimacy
- Anxiolytic effects
- Pain modulation
- Post-orgasmic well-being
Related comparisons
Research and educational reference only. Not medical advice.