Kisspeptin-10 (HPG Axis) vs Pregnenolone
A side-by-side research comparison of Kisspeptin-10 (HPG Axis) and Pregnenolone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Kisspeptin-10 (HPG Axis) | Pregnenolone |
|---|---|---|
| Full name | Kisspeptin-10 (Metastin 45-54) | Pregnenolone (Mother Hormone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | Research compound | OTC supplement / Prescribed |
| Mechanism | Binds KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This cascades to LH/FSH secretion from the pituitary, maintaining the natural feedback loop. | Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity. |
| Molecular weight | 1302.5 Da | 316.48 Da |
| Half-life | ~28 minutes (IV); ~4 hours (SubQ) | ~1-3 hours (oral) |
| Bioavailability | ~90% (subcutaneous) | ~60% oral |
| Typical dose | 100-400 mcg | 50-100 mg |
| Frequency | 1-2x daily | Daily (morning) |
| Route | Subcutaneous injection | Oral capsule or sublingual |
Kisspeptin-10 (HPG Axis) reported benefits
- Natural testosterone restoration
- Preserved HPG axis function
- Enhanced libido
- LH/FSH stimulation
- Potential fertility support
- No testicular suppression
Pregnenolone reported benefits
- Hormone precursor balance
- Memory enhancement
- Mood improvement
- Joint support
- Myelin sheath repair
- Stress resilience
Related comparisons
Research and educational reference only. Not medical advice.