DHEA vs Kisspeptin-10 (HPG Axis)
A side-by-side research comparison of DHEA and Kisspeptin-10 (HPG Axis) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | Kisspeptin-10 (HPG Axis) |
|---|---|---|
| Full name | Dehydroepiandrosterone | Kisspeptin-10 (Metastin 45-54) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | Research compound |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Binds KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This cascades to LH/FSH secretion from the pituitary, maintaining the natural feedback loop. |
| Molecular weight | 288.42 Da | 1302.5 Da |
| Half-life | 15-38 hours | ~28 minutes (IV); ~4 hours (SubQ) |
| Bioavailability | ~100% oral | ~90% (subcutaneous) |
| Typical dose | 25-100 mg | 100-400 mcg |
| Frequency | Daily (morning) | 1-2x daily |
| Route | Oral capsule or topical cream | Subcutaneous injection |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Kisspeptin-10 (HPG Axis) reported benefits
- Natural testosterone restoration
- Preserved HPG axis function
- Enhanced libido
- LH/FSH stimulation
- Potential fertility support
- No testicular suppression
Related comparisons
Research and educational reference only. Not medical advice.