Glutathione (IV/IM) vs NAC
A side-by-side research comparison of Glutathione (IV/IM) and NAC across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Glutathione (IV/IM) | NAC |
|---|---|---|
| Full name | L-Glutathione (Reduced, Injectable) | N-Acetyl Cysteine |
| Category | Detox & Antioxidant | Detox & Antioxidant |
| Status | Compounded / Prescription | Dietary supplement / FDA-approved (Mucomyst) |
| Mechanism | Directly conjugates with toxins, heavy metals, and reactive oxygen species via glutathione S-transferases. Regenerates vitamins C and E. Maintains thiol redox status. Supports Phase II liver detoxification. | Provides cysteine for glutathione synthesis (rate-limiting step). Directly scavenges free radicals via sulfhydryl group. Chelates mercury, lead, and arsenic. Modulates glutamate via system Xc- transporter for neuropsychiatric effects. |
| Molecular weight | 307.32 Da | 163.19 Da |
| Half-life | ~2-3 hours (IV bolus) | ~5.6 hours |
| Bioavailability | 100% (IV); ~60% (IM); ~5-10% (oral) | ~6-10% oral (poor but effective due to GSH replenishment) |
| Typical dose | 600-2000 mg IV push or 200-600 mg IM | 600-1800 mg |
| Frequency | 1-3x weekly | 1-2x daily |
| Route | Intravenous push or intramuscular injection | Oral capsule or IV (hospital) |
Glutathione (IV/IM) reported benefits
- Heavy metal detoxification
- Liver support and protection
- Skin brightening/lightening
- Immune system enhancement
- Mitochondrial protection
- Anti-aging (oxidative stress reduction)
NAC reported benefits
- Glutathione replenishment
- Liver protection (acetaminophen, alcohol)
- Heavy metal chelation
- Mucus thinning (respiratory)
- OCD/addiction support
- Anti-inflammatory
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Research and educational reference only. Not medical advice.