EDTA Chelation vs Glutathione (IV/IM)
A side-by-side research comparison of EDTA Chelation and Glutathione (IV/IM) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | EDTA Chelation | Glutathione (IV/IM) |
|---|---|---|
| Full name | Calcium Disodium EDTA (CaNa2EDTA) | L-Glutathione (Reduced, Injectable) |
| Category | Detox & Antioxidant | Detox & Antioxidant |
| Status | FDA Approved (lead poisoning) / Off-label | Compounded / Prescription |
| Mechanism | Hexadentate chelator forming stable complexes with Pb²⁺, Cd²⁺, Hg²⁺, and Ca²⁺ from arterial plaque. Metal-EDTA complexes are water-soluble and excreted renally. Also reduces oxidative stress from heavy metal catalyzed Fenton reactions. | Directly conjugates with toxins, heavy metals, and reactive oxygen species via glutathione S-transferases. Regenerates vitamins C and E. Maintains thiol redox status. Supports Phase II liver detoxification. |
| Molecular weight | 374.27 Da (disodium EDTA) | 307.32 Da |
| Half-life | ~1.5 hours (IV) | ~2-3 hours (IV bolus) |
| Bioavailability | ~5% oral; 100% IV | 100% (IV); ~60% (IM); ~5-10% (oral) |
| Typical dose | 1.5-3g IV over 1-3 hours | 600-2000 mg IV push or 200-600 mg IM |
| Frequency | Weekly or biweekly | 1-3x weekly |
| Route | Intravenous infusion | Intravenous push or intramuscular injection |
EDTA Chelation reported benefits
- Lead and heavy metal removal
- Reduced cardiovascular events (TACT trial)
- Arterial calcium removal
- Reduced oxidative stress
- Improved vascular function
Glutathione (IV/IM) reported benefits
- Heavy metal detoxification
- Liver support and protection
- Skin brightening/lightening
- Immune system enhancement
- Mitochondrial protection
- Anti-aging (oxidative stress reduction)
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Research and educational reference only. Not medical advice.