EDTA Chelation vs NAC
A side-by-side research comparison of EDTA Chelation and NAC across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | EDTA Chelation | NAC |
|---|---|---|
| Full name | Calcium Disodium EDTA (CaNa2EDTA) | N-Acetyl Cysteine |
| Category | Detox & Antioxidant | Detox & Antioxidant |
| Status | FDA Approved (lead poisoning) / Off-label | Dietary supplement / FDA-approved (Mucomyst) |
| Mechanism | Hexadentate chelator forming stable complexes with Pb²⁺, Cd²⁺, Hg²⁺, and Ca²⁺ from arterial plaque. Metal-EDTA complexes are water-soluble and excreted renally. Also reduces oxidative stress from heavy metal catalyzed Fenton reactions. | Provides cysteine for glutathione synthesis (rate-limiting step). Directly scavenges free radicals via sulfhydryl group. Chelates mercury, lead, and arsenic. Modulates glutamate via system Xc- transporter for neuropsychiatric effects. |
| Molecular weight | 374.27 Da (disodium EDTA) | 163.19 Da |
| Half-life | ~1.5 hours (IV) | ~5.6 hours |
| Bioavailability | ~5% oral; 100% IV | ~6-10% oral (poor but effective due to GSH replenishment) |
| Typical dose | 1.5-3g IV over 1-3 hours | 600-1800 mg |
| Frequency | Weekly or biweekly | 1-2x daily |
| Route | Intravenous infusion | Oral capsule or IV (hospital) |
EDTA Chelation reported benefits
- Lead and heavy metal removal
- Reduced cardiovascular events (TACT trial)
- Arterial calcium removal
- Reduced oxidative stress
- Improved vascular function
NAC reported benefits
- Glutathione replenishment
- Liver protection (acetaminophen, alcohol)
- Heavy metal chelation
- Mucus thinning (respiratory)
- OCD/addiction support
- Anti-inflammatory
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Research and educational reference only. Not medical advice.