Best Peptides for Heart Health

Cardioprotective peptides in research - BPC-157, thymosin beta-4, and compounds supporting cardiovascular function.

BPC-157

A pentadecapeptide derived from human gastric juice that promotes wound healing and tissue repair. Demonstrates remarkable regenerative properties across multiple tissue types including tendon, muscle

Dose: 250-500 mcg per dose | Route: Subcutaneous injection (or oral capsules)

Read full BPC-157 guide →

Thymosin Beta-4

A 43-amino acid peptide that is the primary G-actin sequestering molecule in mammalian cells. Plays a critical role in tissue repair, regeneration, and protection after injury.

Dose: 1-5 mg | Route: Subcutaneous injection

Read full Thymosin Beta-4 guide →

MOTS-c

A mitochondria-derived peptide that acts as an exercise mimetic, improving metabolic homeostasis, insulin sensitivity, and fat oxidation. Levels decline significantly with age.

Dose: 5-10 mg | Route: Subcutaneous injection

Read full MOTS-c guide →

SS-31 (Elamipretide)

A mitochondria-targeted tetrapeptide concentrating 1000-5000x in inner mitochondrial membrane. Stabilizes cardiolipin and optimizes electron transport. In clinical trials for Barth syndrome and heart

Dose: 5-40 mg | Route: Subcutaneous or IV

Read full SS-31 (Elamipretide) guide →

Humanin

A 24-amino acid mitochondria-derived peptide with cytoprotective effects against Alzheimer toxicity, oxidative stress, and apoptosis. Levels decline significantly with age.

Dose: 1-5 mg | Route: Subcutaneous

Read full Humanin guide →

Nattokinase

A fibrinolytic enzyme extracted from natto (fermented soybeans) with potent clot-dissolving properties. Used for cardiovascular protection, blood pressure reduction, and as a natural alternative to ph

Dose: 2000-4000 FU (fibrinolytic units) | Route: Oral capsule

Read full Nattokinase guide →

Serrapeptase

A proteolytic enzyme originally isolated from Serratia bacteria in silkworm intestines. Used for its anti-inflammatory, fibrinolytic, and mucolytic properties. Popular for arterial plaque reduction an

Dose: 120,000-240,000 SPU | Route: Oral (enteric-coated)

Read full Serrapeptase guide →

CoQ10

A fat-soluble electron carrier essential for mitochondrial ATP production. The reduced form (ubiquinol) is the body's most potent lipid-soluble antioxidant. Critical for cardiac function, statin u

Dose: 100-300 mg ubiquinol | Route: Oral softgel

Read full CoQ10 guide →

Omega-3 (EPA/DHA)

Essential polyunsaturated fatty acids that form the backbone of anti-inflammatory signaling. EPA and DHA reduce triglycerides, stabilize cardiac rhythm, reduce platelet aggregation, and resolve chroni

Dose: 2-4g combined EPA+DHA | Route: Oral (softgel, liquid)

Read full Omega-3 (EPA/DHA) guide →

Bergamot Extract

A polyphenol-rich citrus extract from Calabrian bergamot with statin-like HMGCR inhibition. Reduces LDL cholesterol, improves HDL, and lowers blood glucose - making it a natural alternative or adjunct

Dose: 500-1000 mg standardized extract | Route: Oral capsule

Read full Bergamot Extract guide →

Telmisartan

An FDA-approved angiotensin receptor blocker (ARB) for blood pressure that is a favorite in longevity circles because, unlike other ARBs, it also partially activates PPAR-gamma, giving it metabolic an

Dose: 20-80 mg per day | Route: Oral tablet

Read full Telmisartan guide →

Vesugen

A short synthetic tripeptide bioregulator from the Khavinson family, targeted at vascular tissue. It is used within the peptide-bioregulator community for vascular health and endothelial support, typi

Dose: ~1-2 capsules/day or short injectable courses | Route: Oral capsule or subcutaneous

Read full Vesugen guide →

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