MXE (Methoxetamine)

Category: Psychedelics. Status: Schedule I (research compound).

A dissociative chemically related to ketamine, with a longer duration and stronger psychedelic quality. Studied in research and known from harm-reduction reports.

How it works

Blocks NMDA glutamate receptors and affects dopamine, producing dissociation and detachment.

Key facts

• Molecular weight: 247.33 g/mol
• Half-life: Moderate
• Bioavailability: Oral
• Storage: Research/reference only.

Dosing overview

• Typical dose: Varies by individual and setting
• Frequency: Occasional
• Duration: Acute effects last 2-4 hours
• Route: Oral

Protocol notes

• Taken orally, sublingually or insufflated; longer-acting than ketamine.
• Used lying down because of strong dissociation and fall risk.

Reported benefits

• Longer than ketamine
• Dissociative-psychedelic blend
• Research dissociative
• Studied in harm reduction

Possible side effects

• Strong dissociation
• Raised heart rate and blood pressure
• Risk of overdose and confusion
• Limited safety data

Compare MXE

• MXE vs MDMA
• MXE vs Psilocybin
• MXE vs LSD
• MXE vs Ibogaine
• MXE vs DMT
• MXE vs Ayahuasca

Research and educational reference only. Not medical advice.