Salvinorin A Research Guide

Full name: Salvinorin A (Salvia divinorum)

The active compound in the Salvia divinorum plant and one of the most potent natural psychedelics known. It produces a very short but intensely disorienting experience and works through a completely different pathway than classic psychedelics.

How Salvinorin A Works

Activates kappa-opioid receptors (not serotonin receptors), which makes its effects unlike LSD or psilocybin.

Dosing Protocol

• Typical dose: Varies by individual and setting
• Frequency: Occasional
• Duration: Acute effects last 5-20 minutes
• Route: Smoked, vaporized or held in the mouth

Reported Benefits

• Unique kappa-opioid mechanism
• Very short experience
• Long traditional Mazatec use
• Of interest for depression research

Potential Side Effects

• Intense disorientation
• Loss of awareness of surroundings (fall risk)
• Anxiety or fear
• Brief but overwhelming

Related Psychedelics Compounds

• MDMA - Full Profile
• Psilocybin - Full Profile
• LSD - Full Profile
• Ibogaine - Full Profile
• DMT - Full Profile
• Ayahuasca - Full Profile

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