Psilocybin Research Guide

Full name: Psilocybin (from psilocybin mushrooms)

The main psychedelic compound in "magic mushrooms," studied for depression, anxiety, addiction and end-of-life distress. In supervised sessions it can produce a profound shift in perspective that many people find long-lasting.

How Psilocybin Works

Converted in the body to psilocin, which activates serotonin 5-HT2A receptors in the brain. This temporarily loosens rigid thinking patterns and increases connectivity between brain networks.

Dosing Protocol

• Typical dose: 10-30 mg in clinical trials
• Frequency: One to a few supervised sessions
• Duration: Acute effects last 4-6 hours
• Route: Oral, in a supervised therapeutic setting

Reported Benefits

• Studied for treatment-resistant depression
• Eases anxiety in life-threatening illness
• Explored for alcohol and tobacco addiction
• Often produces durable improvements after few doses

Potential Side Effects

• Anxiety or fear during the experience
• Nausea
• Raised heart rate and blood pressure
• Temporary confusion
• Risk of distressing experiences without proper support

Research Citations

1. Psilocybin for treatment-resistant depression (2022) - A single 25 mg dose with psychological support significantly reduced depression scores compared with lower doses.
2. Psilocybin-assisted therapy for cancer-related distress (2016) - Produced rapid and sustained reductions in anxiety and depression in patients with life-threatening cancer.

Related Psychedelics Compounds

• MDMA - Full Profile
• LSD - Full Profile
• Ibogaine - Full Profile
• DMT - Full Profile
• Ayahuasca - Full Profile
• 5-MeO-DMT - Full Profile

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