Mescaline Research Guide

Full name: Mescaline (from peyote and San Pedro cactus)

One of the oldest known psychedelics, found in peyote and San Pedro cacti and used ceremonially for thousands of years. Of growing interest in modern mental-health research.

How Mescaline Works

Activates serotonin 5-HT2A receptors, producing long-lasting changes in perception and mood. It is a phenethylamine rather than a tryptamine.

Dosing Protocol

• Typical dose: Several hundred milligrams (study and traditional use)
• Frequency: Occasional or ceremonial
• Duration: Acute effects last 10-12 hours
• Route: Oral

Reported Benefits

• Long history of ceremonial use
• Survey data links use to wellbeing
• Renewed research interest
• Distinct phenethylamine profile

Potential Side Effects

• Strong nausea and vomiting
• Very long experience
• Anxiety or fear
• Raised heart rate and blood pressure

Research Citations

1. Naturalistic study of mescaline use and mental health (2021) - Survey participants commonly reported improvements in depression, anxiety and substance use after a mescaline experience.

Related Psychedelics Compounds

• MDMA - Full Profile
• Psilocybin - Full Profile
• LSD - Full Profile
• Ibogaine - Full Profile
• DMT - Full Profile
• Ayahuasca - Full Profile

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