HMG Research Guide

Full name: Human Menopausal Gonadotropin (Menotropins)

A purified preparation of FSH and LH extracted from postmenopausal urine. Used in fertility medicine to stimulate spermatogenesis in men and ovarian follicle development in women. Essential for TRT-induced azoospermia recovery.

How HMG Works

FSH component directly stimulates Sertoli cells to support spermatogenesis in men, and granulosa cells for follicle growth in women. LH component stimulates Leydig cells (testosterone) in men and theca cells (androgen precursors) in women.

Dosing Protocol

• Typical dose: 75-150 IU
• Frequency: 3x weekly (men) or daily (women, stimulation)
• Duration: 3-6 months (men); 8-12 days (women IVF)
• Route: Intramuscular or subcutaneous injection

Reported Benefits

• Spermatogenesis restoration
• Ovarian follicle stimulation
• Fertility recovery after TRT
• Improved sperm count and motility
• IVF protocol support

Potential Side Effects

• Injection site pain
• Ovarian hyperstimulation (women)
• Headache
• Mood swings
• Gynecomastia (men, rare)
• Multiple pregnancy risk (women)

Research Citations

1. HMG for TRT-induced azoospermia (2021) - HMG + HCG combination restored spermatogenesis in 85% of previously azoospermic TRT patients within 6-12 months.
2. Gonadotropins and male fertility (2022) - FSH/LH therapy improved sperm concentration from 0 to >5 million/mL in 70% of men with hypogonadotropic hypogonadism.

Related Fertility Compounds

• Letrozole - Full Profile
• HCG (Fertility) - Full Profile

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