HCG (Fertility) Research Guide

Full name: HCG for Ovulation Trigger (Pregnyl/Ovidrel)

Used as an ovulation trigger in assisted reproduction protocols. The LH-mimicking activity of HCG causes final oocyte maturation and ovulation approximately 36 hours after injection, timing intercourse or egg retrieval.

How HCG (Fertility) Works

Binds LH/CG receptors on the dominant follicle, triggering resumption of meiosis in the oocyte, luteinization of granulosa cells, and follicular rupture (ovulation) within 36-40 hours of administration.

Dosing Protocol

• Typical dose: 5000-10,000 IU (Pregnyl) or 250 mcg (Ovidrel)
• Frequency: Single injection timed to follicle maturity
• Duration: Per cycle
• Route: Subcutaneous or intramuscular

Reported Benefits

• Precise ovulation timing
• Final oocyte maturation
• Corpus luteum support
• IUI/IVF timing coordination
• Luteal phase support

Potential Side Effects

• Ovarian hyperstimulation risk
• Bloating
• Breast tenderness
• Mood changes
• Pelvic discomfort
• Multiple pregnancy risk

Research Citations

1. HCG trigger timing in IUI cycles (2021) - HCG trigger at 18mm follicle size optimized pregnancy rates (22% per cycle) vs earlier or later trigger timing.
2. Dual trigger (GnRH agonist + low-dose HCG) (2022) - Dual trigger reduced OHSS incidence by 90% while maintaining equivalent oocyte yield in high-responder IVF patients.

Related Fertility Compounds

• HMG - Full Profile
• Letrozole - Full Profile

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