Selank vs Synapsin
A side-by-side research comparison of Selank and Synapsin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Selank | Synapsin |
|---|---|---|
| Full name | Selank (TP-7) | Synapsin Nasal Spray (RG3 + NAD+ + Methylcobalamin) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Compounded medication |
| Mechanism | Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance. | Rg3 reduces neuroinflammation and protects neurons. NAD+ supports mitochondrial function and sirtuin activation in brain cells. Methylcobalamin provides methylation support and myelin repair. Nasal route bypasses BBB for direct CNS delivery. |
| Molecular weight | 751.9 Da | Combination compound |
| Half-life | 3-5 min (IV) / 15-30 min (intranasal) | Variable (nasal depot effect) |
| Bioavailability | Moderate (intranasal) | ~60-80% nasal (direct CNS access) |
| Typical dose | 250-750 mcg per spray dose | 1-2 sprays per nostril |
| Frequency | 2-3x daily | 1-2x daily |
| Route | Intranasal spray | Intranasal spray |
Selank reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
Synapsin reported benefits
- Improved mental clarity
- Reduced brain fog
- Neuroprotection
- Enhanced focus
- Nerve repair support
- Anti-neuroinflammatory
Related comparisons
Research and educational reference only. Not medical advice.