NMN vs SS-31 (Elamipretide)
A side-by-side research comparison of NMN and SS-31 (Elamipretide) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | NMN | SS-31 (Elamipretide) |
|---|---|---|
| Full name | Nicotinamide Mononucleotide | SS-31 / Elamipretide (Bendavia) |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Investigational |
| Mechanism | NMN is converted to NAD+ via the NAD+ salvage pathway (through NMNAT enzymes). Higher NAD+ supports sirtuin activity, PARP-mediated DNA repair, and mitochondrial energy metabolism. | Targets cardiolipin in inner mitochondrial membrane, stabilizes cytochrome c binding, optimizes electron transfer efficiency, and reduces mitochondrial ROS by 50%. |
| Molecular weight | 334.22 Da | 640.8 Da |
| Half-life | Short; rapidly taken up and converted to NAD+ | 4-6 hours |
| Bioavailability | Oral absorption reported; sublingual and injectable forms also used | High (SubQ) |
| Typical dose | 250-1000 mg per day | 5-40 mg |
| Frequency | Once daily | Daily |
| Route | Oral (capsule/sublingual) | Subcutaneous or IV |
NMN reported benefits
- Raises cellular NAD+ levels
- Supports mitochondrial energy production
- Promotes DNA repair via sirtuins/PARPs
- Studied for metabolic and vascular health
SS-31 (Elamipretide) reported benefits
- Mitochondrial function optimization
- Reduced oxidative stress
- Cardioprotection
- Improved exercise capacity
- Renal protection
- Cellular energy
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Research and educational reference only. Not medical advice.