IGF-1 LR3 vs PEG-MGF
A side-by-side research comparison of IGF-1 LR3 and PEG-MGF across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | IGF-1 LR3 | PEG-MGF |
|---|---|---|
| Full name | Insulin-like Growth Factor-1 Long R3 | PEGylated Mechano Growth Factor |
| Category | Muscle Growth | Muscle Growth |
| Status | Research compound | Research compound |
| Mechanism | Activates IGF-1R while evading IGFBP sequestration. Triggers PI3K/Akt/mTOR for protein synthesis, satellite cell proliferation, and amino acid uptake into muscle. | PEGylation protects MGF from rapid degradation, extending half-life from minutes to hours. Activates satellite cells systemically for whole-body muscle recovery. |
| Molecular weight | 9,111 Da | ~5000 Da (with PEG) |
| Half-life | 20-30 hours (vs 15 min native) | ~30 minutes to several hours (vs 5-7 min native) |
| Bioavailability | High (SubQ/IM) | ~85% subcutaneous |
| Typical dose | 20-50 mcg | 100-200 mcg |
| Frequency | Daily (post-workout) | 2-3x per week |
| Route | Subcutaneous or intramuscular injection | Subcutaneous injection |
IGF-1 LR3 reported benefits
- Potent anabolic effects
- Hyperplasia (new muscle cells)
- Extended half-life
- Enhanced recovery
- Improved nutrient partitioning
- Satellite cell activation
PEG-MGF reported benefits
- Extended half-life vs native MGF
- Systemic satellite cell activation
- Whole-body recovery
- Less frequent dosing
Related comparisons
Research and educational reference only. Not medical advice.