5-MeO-DMT vs DXM
A side-by-side research comparison of 5-MeO-DMT and DXM across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | 5-MeO-DMT | DXM |
|---|---|---|
| Full name | 5-Methoxy-N,N-dimethyltryptamine | Dextromethorphan |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Over-the-counter cough suppressant (psychedelic at high doses) |
| Mechanism | Strongly activates serotonin 5-HT1A and 5-HT2A receptors, producing rapid and intense changes in consciousness. | At high doses it blocks NMDA glutamate receptors, producing dissociation similar to ketamine. |
| Molecular weight | 218.30 g/mol | 271.40 g/mol |
| Half-life | Short (minutes) | ~3-6 hours |
| Bioavailability | Inhaled/injected | Oral |
| Typical dose | Low milligram range in clinical studies | Varies by individual and setting |
| Frequency | One to a few supervised sessions | Occasional |
| Route | Inhalation or injection in research settings | Oral |
5-MeO-DMT reported benefits
- Studied for treatment-resistant depression
- Short duration suits clinical use
- Explored for anxiety
- Rapid onset of effects
DXM reported benefits
- Widely studied cough medicine
- Dissociative effects at high doses
- Included for awareness
- Researched for mood (as a combo drug)
Related comparisons
Research and educational reference only. Not medical advice.