DXM (Dextromethorphan)

Category: Psychedelics. Status: Over-the-counter cough suppressant (psychedelic at high doses).

A common cough-medicine ingredient that becomes a powerful dissociative psychedelic at high doses. Included for awareness because of how widely available it is.

How it works

At high doses it blocks NMDA glutamate receptors, producing dissociation similar to ketamine.

Key facts

• Molecular weight: 271.40 g/mol
• Half-life: ~3-6 hours
• Bioavailability: Oral
• Storage: Research/reference only.

Dosing overview

• Typical dose: Varies by individual and setting
• Frequency: Occasional
• Duration: Acute effects last 4-8 hours
• Route: Oral

Protocol notes

• Taken orally at high doses from cough syrup or gel caps for a dissociative effect.
• Very dangerous with antidepressants (serotonin syndrome) and in combo cough products (liver risk).
• Listed for awareness given how easy it is to get.

Reported benefits

• Widely studied cough medicine
• Dissociative effects at high doses
• Included for awareness
• Researched for mood (as a combo drug)

Possible side effects

• Nausea and vomiting
• Dangerous interactions with SSRIs (serotonin syndrome)
• Confusion and impaired coordination
• Liver risk from combo products

Compare DXM

• DXM vs MDMA
• DXM vs Psilocybin
• DXM vs LSD
• DXM vs Ibogaine
• DXM vs DMT
• DXM vs Ayahuasca

Research and educational reference only. Not medical advice.