Harmaline (Harmaline (harmala alkaloid))
A natural compound from Syrian rue and the ayahuasca vine. It is an MAO inhibitor that makes oral DMT active, and at higher doses produces its own dreamy, sedating effects.
How it works
Inhibits the enzyme MAO-A, which lets oral DMT work; also has mild psychedelic and sedative effects of its own.
Key facts
- Molecular weight: 214.26 g/mol
- Half-life: Several hours
- Bioavailability: Oral
- Storage: Research/reference only.
Dosing overview
- Typical dose: Varies by individual and setting
- Frequency: Occasional
- Duration: Acute effects last 4-8 hours
- Route: Oral
Protocol notes
- Used mainly as the MAO-inhibiting half of ayahuasca, taken before or with the DMT-containing plant.
- On its own it can be taken orally for a dreamy, sedating effect with strong nausea.
- Because it is an MAO inhibitor, certain foods and many medications must be avoided.
Reported benefits
- Enables oral DMT (ayahuasca)
- Studied in ethnobotany
- Natural harmala alkaloid
- Dreamy effects at higher doses
Possible side effects
- Dangerous MAOI food and drug interactions
- Strong nausea and vomiting
- Sedation
- Tremor
Compare Harmaline
Research and educational reference only. Not medical advice.