Bufotenin (5-Hydroxy-DMT)
A naturally occurring tryptamine found in some toads, plants and seeds (like yopo snuff). Closely related to DMT and 5-MeO-DMT and used traditionally in snuffs.
How it works
Activates serotonin receptors; has strong peripheral cardiovascular effects in addition to central effects.
Key facts
- Molecular weight: 204.27 g/mol
- Half-life: Short
- Bioavailability: Oral
- Storage: Research/reference only.
Dosing overview
- Typical dose: Varies by individual and setting
- Frequency: Occasional
- Duration: Acute effects short
- Route: Insufflated (snuff) or injected
Protocol notes
- Historically used in snuffs (yopo) made from seeds, blown into the nose.
- Produces strong body effects, so traditional use is always in a supported group setting.
Reported benefits
- Found in traditional snuffs (yopo)
- Closely related to DMT
- Studied in ethnobotany
- Natural tryptamine
Possible side effects
- Strong cardiovascular effects
- Nausea and vomiting
- Facial flushing
- Limited modern safety data
Community reviews of Bufotenin
- dad918 rated it 5/5 - Better mental clarity for long runs: Anecdotally, this helped my focus during my ultra training. My mental fog just vanished. I felt more present while running through the woods. I am very happy with how it felt. It seemed to sharpen my mind.
- jordan_codes rated it 2/5 - Slight head‑fog, no clear benefit: I tried bufotenin hoping it would sharpen my focus for night shifts, but after 12 weeks I mostly felt a lingering light haze and occasional nausea. My HRV and sleep metrics stayed flat, and I didn’t notice any mental edge, so overall it was disappointing.
Compare Bufotenin
Research and educational reference only. Not medical advice.