ResearchSafe

4-HO-MET (4-Hydroxy-N-methyl-N-ethyltryptamine (metocin))

Category: Psychedelics. Status: Schedule I (research compound).

A synthetic tryptamine related to psilocin, known for a gentle, colorful and emotionally warm experience. Used mainly in research and self-experimentation contexts.

How it works

Activates serotonin 5-HT2A receptors, similar to other classic tryptamine psychedelics.

Key facts

  • Molecular weight: 218.30 g/mol
  • Half-life: ~2 hours
  • Bioavailability: Oral
  • Storage: Research/reference only.

Dosing overview

  • Typical dose: Varies by individual and setting
  • Frequency: Occasional
  • Duration: Acute effects last 4-6 hours
  • Route: Oral

Protocol notes

  • Taken orally in measured doses for a gentle, colorful, emotionally warm experience.
  • Used in calm settings; onset is around 30-60 minutes and effects last 4-6 hours.

Reported benefits

  • Gentle, visual experience
  • Related to psilocin
  • Studied as a research psychedelic
  • Lower body load reported

Possible side effects

  • Anxiety or fear
  • Nausea
  • Raised heart rate
  • Limited human safety data

Community reviews of 4-HO-MET

Rated 3.7 out of 5 from 3 community reviews by ResearchSafe members.

  • rational_coldplunge758 rated it 4/5 - Better mental clarity for my CrossFit planning: For me, the biggest change was how it cleared my head to organize my athletes' programs. It felt more or less like a gentle lift in mood without the heavy body load, no? Just my own experience, but it made my focus very sharp for a few hours ⚡.
  • restlessdiego rated it 5/5 - Much lighter on the system than psilocin: My biggest win was the lower body load. Since I am always on my feet as a therapist, I cannot handle heavy physical fatigue. For me, this felt much gentler on my muscles (which is a beauty), fwiw. It just seemed to provide a cleaner, visual experience without the exhaustion 📋.
  • leah_j rated it 2/5 - Not the focus boost I wanted: Tried this for ten weeks to help my freelance writing flow? Just felt an annoying heaviness in my chest? My focus didn't actually shift much at all. For me it was just a let down. Maybe just a placebo effect or my own weird chemistry? Definitely not for me ⚡

Compare 4-HO-MET

Research and educational reference only. Not medical advice.