ResearchSafe

2C-I (4-Iodo-2,5-dimethoxyphenethylamine)

Category: Psychedelics. Status: Schedule I (research compound).

A 2C-family psychedelic with bright, energetic visuals and a stimulating quality. One of Shulgin's well-documented phenethylamines.

How it works

Activates serotonin 5-HT2A receptors.

Key facts

  • Molecular weight: 307.13 g/mol
  • Half-life: ~2 hours
  • Bioavailability: Oral
  • Storage: Research/reference only.

Dosing overview

  • Typical dose: Varies by individual and setting
  • Frequency: Occasional
  • Duration: Acute effects last 6-8 hours
  • Route: Oral

Protocol notes

  • Taken orally for bright, energetic visuals lasting 6-8 hours.
  • Used in calm settings; the stimulating quality can add to anxiety at high doses.

Reported benefits

  • Bright, energetic visuals
  • Stimulating
  • Shulgin research compound
  • Moderate duration

Possible side effects

  • Anxiety
  • Nausea
  • Raised heart rate
  • Dose-sensitive

Community reviews of 2C-I

Rated 4 out of 5 from 3 community reviews by ResearchSafe members.

  • cora_zone2 rated it 4/5 - Visual focus boost helped my night‑shift rounds: For what it’s worth, the vivid colour pop and sharper peripheral vision lasted a few hours after a low dose, making my night‑shift patient checks feel less tiring; I felt a mild jitter that eased after an hour, otherwise it was pretty clean.
  • nomad_ingrid rated it 4/5 - bright trip, but the comedown surprised me: i tried 2c‑i a few months back because i was curious if a short, vivid psychedelic could give me a creative boost between grading papers and coaching the school track team. the peak was exactly what i expected – intense colors, fast‑moving patterns and a buzz that felt more stimulating than mellow. it lasted just under three hours, so it didn’t mess with my sleep schedule. the only downside was a surprisingly low‑key crash that left me a bit foggy for the rest of the day, which was annoying when i still had lesson plans to finish. overall, i’d give it four stars.
  • data_labrat rated it 4/5 - bright boost for a mid‑season slump: i was dragging through a rainy week of box‑jumps and client meetings, feeling fuzzy and low on spark. i tried a modest 15 mg of 2c‑i after a light dinner, just to see if the visual buzz could shake the fog. within an hour the colors in the gym felt sharper, my thoughts raced with a clean focus and i actually enjoyed the squat set. the high tapered off after three hours, leaving a mild after‑glow but a tiny headache that lingered. overall, solid lift for the day, just watch the tail‑end.

Compare 2C-I

Research and educational reference only. Not medical advice.