2C-E (4-Ethyl-2,5-dimethoxyphenethylamine)
A more intense member of the 2C family, known for deep, introspective and strongly visual experiences. Documented in Shulgin's research.
How it works
Activates serotonin 5-HT2A receptors.
Key facts
- Molecular weight: 209.29 g/mol
- Half-life: ~2-3 hours
- Bioavailability: Oral
- Storage: Research/reference only.
Dosing overview
- Typical dose: Varies by individual and setting
- Frequency: Occasional
- Duration: Acute effects last 6-10 hours
- Route: Oral
Protocol notes
- Taken orally; deeper and more introspective than 2C-B, so used in quiet settings.
- Onset can be slow, which sometimes leads people to redose too early (a mistake).
Reported benefits
- Deep, introspective effects
- Strong visuals
- Shulgin research compound
- Distinct from 2C-B
Possible side effects
- Anxiety and confusion
- Nausea
- Body load
- Dose-sensitive
Community reviews of 2C-E
- peptidehead_honest rated it 2/5 - Felt mostly flat, a brief color wash: I tried 2C‑E hoping for a deep mental shift before my conference, but after three weeks the only noticeable thing was a short, faint visual tint that faded quickly. It didn’t help my focus or mood, and I felt a bit uneasy afterward. 😐
- busy_mobility rated it 5/5 - Brilliant for my mental clutter: Being a sales rep is a mental grind, so i tried this to clear my head. For me, the introspective side was spot on. It seemed to help me sort through a lot of stress and just felt brilliant.
- student748 rated it 4/5 - visuals cleared mental fog after long runs: for what it’s worth, the biggest thing i noticed was how 2c‑e sharpened my mind during the post‑run crash – colours felt richer and thoughts lined up clearer, which helped me process training stress. the trip was intense, but a bit much on the comedown.
Compare 2C-E
Research and educational reference only. Not medical advice.