VIP Research Guide

Full name: Vasoactive Intestinal Peptide

A 28-amino-acid signaling peptide found throughout the nervous and immune systems. Studied for its anti-inflammatory and immune-modulating effects, and used intranasally in some chronic inflammatory protocols (e.g. CIRS / mold-illness frameworks).

How VIP Works

Activates VPAC1 and VPAC2 receptors, raising intracellular cAMP. This dampens pro-inflammatory cytokine production, supports vasodilation and pulmonary function, and modulates regulatory T-cell activity.

Dosing Protocol

• Typical dose: ~50 mcg per spray
• Frequency: 1-4x daily
• Duration: Weeks to months
• Route: Intranasal spray

Reported Benefits

• Broad anti-inflammatory effect
• Supports pulmonary and vascular function
• Immune modulation (regulatory T cells)
• Used in chronic inflammatory response protocols

Potential Side Effects

• Transient drop in blood pressure
• Flushing
• Nasal irritation (intranasal)
• Lightheadedness

Research Citations

1. VIP as an immunomodulatory neuropeptide (2019) - Reviewed VIP's role in shifting immune responses toward an anti-inflammatory, tolerogenic profile.
2. Intranasal VIP in chronic inflammatory illness (2018) - Reported improvements in inflammatory markers and quality of life in observational use.

Related Immune Support Compounds

• Thymosin Alpha-1 - Full Profile
• Thymulin - Full Profile
• Lactoferrin - Full Profile
• Beta-Defensin - Full Profile
• TA1 - Full Profile
• Thymalin - Full Profile

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