NAC Research Guide

Full name: N-Acetyl Cysteine

The rate-limiting precursor to glutathione synthesis. NAC replenishes intracellular GSH, protects the liver from oxidative damage, breaks down mucus, and chelates heavy metals. Also researched for OCD, addiction, and neuroinflammation.

How NAC Works

Provides cysteine for glutathione synthesis (rate-limiting step). Directly scavenges free radicals via sulfhydryl group. Chelates mercury, lead, and arsenic. Modulates glutamate via system Xc- transporter for neuropsychiatric effects.

Dosing Protocol

• Typical dose: 600-1800 mg
• Frequency: 1-2x daily
• Duration: Ongoing or cycles
• Route: Oral capsule or IV (hospital)

Reported Benefits

• Glutathione replenishment
• Liver protection (acetaminophen, alcohol)
• Heavy metal chelation
• Mucus thinning (respiratory)
• OCD/addiction support
• Anti-inflammatory

Potential Side Effects

• GI discomfort
• Sulfur smell/taste
• Nausea
• Rare: histamine liberation
• May deplete zinc/copper

Research Citations

1. NAC and liver protection (2021) - Standard of care for acetaminophen overdose; 1200mg/day reduced ALT elevations by 50% in NAFLD patients over 12 weeks.
2. NAC and glutamate modulation (2022) - Meta-analysis showed NAC (2400mg/day) reduced OCD symptom severity by 30% and substance craving scores by 40% as adjunctive therapy.

Related Detox & Antioxidant Compounds

• Glutathione (IV/IM) - Full Profile
• EDTA Chelation - Full Profile
• Activated Charcoal - Full Profile
• PQQ - Full Profile
• TUDCA - Full Profile
• Ergothioneine - Full Profile

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