Rapamycin Pulse vs Metformin: How My Energy and Sleep Have Changed

Posted by grace_sleepnerd in Longevity & Anti-Aging - 2 points, 0 comments.

I started a 3‑mg rapamycin pulse last month, once a week, and added 500 mg metformin in the morning. Before that, I was always buzzing at night and racing through the day, not much sleep quality, and my blood work in the last check‑in showed a little uptick in fasting glucose. Since the change, my sleep has been steadier, no more 4‑hour wake‑ups, and I feel a steadier flow of energy, not the all‑or‑nothing sprint I used to have.

Metformin’s GI upsets were mild and seemed to settle with the food I kept eating, but the overall metabolic check‑outs haven’t gone up. I’ve got no shift in my mood, just a steadier baseline and less post‑workout crash. I’m keeping a diary of the weekly rapamycin, the daily metformin, and noting how my work output and day‑to‑day insight feel.

I’m curious if y’all see a similar pattern or have tweaks that help keep the balance without too many side effects. Imi, any suggestions on timing or dose tweaks?

Community discussion - research and educational context only. Not medical advice.