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Adding Quercetin to my Weekly Rapamycin – Thoughts on Timing and Dose?

Posted by greg208 in Longevity & Anti-Aging - 7 points, 8 comments.

Not gonna lie I’ve been on 3 mg of rapamycin once a week for about three months now and it’s been a bit of a game changer for my sleep and how I feel after a long shift. I’ve read that quercetin is a natural flavonoid that can act as a senolytic and some people pair it with dasatinib for a “fisetin/ dasatinib + quercetin” protocol, but I’m not sure how to fit itiframe absurdo with rapamycin. I’m thinking of hitting 500 mg daily, maybe in the morning, and then keeping the rapamycin on my usual Sunday evening dose.

I’ve heard the half‑life of quercetin is about 11–28 hours, so I’m wondering if there’s any overlap that might affect mTOR inhibition or if the antioxidant effect might just complement it. Anyone out there tried quercetin with rapamycin? How long did it take for you to notice any benefit or any side effects?

Comments

  • hank_m: I’ve been on the same 3 mg rap weekly routine for a while now and added 500 mg quercetin in the morning a few months back, keeping the Sunday night dose, just like you’re planning. I didn’t notice any interference with mTOR inhibition – the rap still hit the same sleep boost and recovery effect – but i did feel a bit clearer in the afternoons, maybe it’s just the antioxidant lift. The half‑life is pretty wide so you’re probably fine with that split, just keep an eye on any new energy spikes or d
  • kayla_s: Sounds good to me, Hank. I started quercetin the same way and it’s been working fine, I haven’t felt any weird “energy spikes,” but I did get a mild stomach itch in the afternoon. Did you notice any timing that glaub best for the appetite or sleep?
  • hank_m: Tbh i’ve been on a similar schedule for a few months, quercetin 500 mg in the morning and rapamycin on sunday night, and i’ve not noticed any obvious interference – my sleep and recovery still feel great, and i haven’t had any new side effects beyond the usual mild stomach upset from the quercetin when i skip a meal. The antioxidant vibe seems to just round out the mTOR block rather than beat it, but i’d keep an eye on energy spikes or dips when switching timing. How long did it take you to catc
  • ivy_mobility: I tried 500 mg quercetin with breakfast and rapamycin Sunday night for six weeks; my Oura HRV stayed stable and I felt no extra fatigue. Did you track any biomarkers or just subjective feel?
  • greg208: Not gonna lie I didn’t do any bloodwork just kept a log of how I felt – sleep quality, energy after night shifts and a quick check on the Oura score. I noticed a bit more restfulness and less muscle soreness after big shifts, but I didn’t notice any weird side‑effects. You mentioned HRV stayed steady – did you see any change in recovery time or lexic or something after the first couple of weeks?
  • greg208: Got it, mate. I kicked quercetin in the morning a few weeks after my rapamycin started; the first change I caught was a smoother night’s sleep about two weeks later. No new gut issues beyond the usual stomach upset when I miss a meal. Energy spikes have been mild, mostly a steady lift through the day. I’ll keep an eye on any dips that line up with the Sunday dose, just like you. Have you noticed any pattern with the timing?
  • greg208: I’ve been taking quercetin at about 7 am with breakfast and the 3 mg rapamycin on Sunday night. CBD the quercetin seems to blunt my late‑evening cravings a bit, so I’m not as tempted to snack after a long shift, and my sleep has stayed steady without extra energy spikes. The mild stomach itch I felt on an empty stomach has gone away when I switch to taking it with food. How long did it take you to notice any changes?
  • greg208: Thanks for the heads‑up, I’m going to start the 500 mg quercetin in the morning and keep the 3 mg rap on Sunday night like you do. I’ll watch for any sudden energy spikes or gut changes you mentioned. Have you noticed any day‑to‑day variation in the sleep boost or recovery after adding quercetin?

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