Amlexanox 25 mg thrice daily: my weight loss and GI side‑effects

Posted by liam_sleepnerd in Weight Loss & Metabolic - 1 points, 0 comments.

I started Amlexanox 25 mg three times a day about two months ago after reading the preclinical data that it can block the kinases that drive obesity‑related insulin resistance, so I thought it might help with my stubborn belly fat and the intermittent low‑grade inflammation that I feel after a hard workout. For the first week I kept a daily log of weight, waist circumference, and heart‑rate variability. I saw a steady drop of 0.3 lb per day and my HRV trending slightly upward, which felt reassuring.

Within the first two days I experienced mild diarrhea and a slight headache; thenaq. I tapered the dose to 15 mg once, then back up to 25 mg as the symptoms subsided. No nausea or injection site issues, just the GI upset that the label warns about.

After four weeks my waist shrank by almost two inches and my fasting glucose dropped modestly, according to the home meter I use. I’m still watching the numbers and tracking how my energy changes during the day. Anyone else noticing a similar pattern after adding Amlexanox?

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