Tbh my first 4 weeks on spermidine with rapamycin – sleep, energy, and skin notes

Posted by hank_m in Longevity & Anti-Aging - 0 points, 0 comments.

Tbh i started spermidine at 5 mg a day and rapamycin 4 mg once a week two months ago to try a combo that mimics caloric restriction and boosts autophagy, and i’ve been keeping a log of what i notice. The first week i woke up with an odd light headache that faded by day three, and i didn’t have any mouth sores which i’ve seen in other people on rapamycin so i thought i might be lucky. Sleep quality has improved – i fall asleep faster, and my dreams feel less jagged, probably because the autophagy boost clears some cellular waste in the brain.

My skin feels firmer, the fine lines around my eyes look less pronounced, i think it’s subtle but i’ve noticed a subtle change in my overall glow. Energy is արդեն steadier, i’m not that “post‑elevated” burst then crash, just a gentle lift that lasts through the day. I’ve kept my diet normal and taken a B12 supplement to cover any potential deficiency from metformin style effects. I’ll keep this for another month and plan to tweak the dose if it feels off.

Community discussion - research and educational context only. Not medical advice.