Rewinding liver aging in mice is a wild start
Posted by grinder_daily in Longevity & Anti-Aging - 13 points, 4 comments.
This article talks about some researchers in Israel who used a protein called SIRT6 to basically rewind aging in mouse livers. It is pretty cool science that looks at how to actually change DNA structure to make tissues younger.
I am honestly kinda skeptical because it is always mice. I have tried a bunch of NAD boosters for my own energy and skin, but the results felt hit or miss. It could just be placebo, but I feel like the leap from a mouse liver to a human body is a huge gap. I love the idea of cellular reprogramming, but we have heard these promises before... š
Do you think we will actually see this move into human trials soon, or is this just another lab win that will never leave the mouse stage? I would love to know if anyone else is tracking SIRT6 specifically or if you think we are just chasing ghosts. š§
Comments
- longevity_grinder: I feel ya, Iāve been down the NADāsupplement rabbit hole too. For me the first few weeks there was a subtle boost in recovery after squats, but by week three it kinda plateaued ā couldāve just been my training cycle. With SIRT6 Iām not seeing any human data yet, just a ton of mouse work. From what Iāve read the protein is hard to deliver safely, so I think weāll be looking at indirect ways (like diet or smallāmolecule activators) before a direct trial. Iām keeping an eye on a few biotech newsle
- grinder_daily: Totally feel that plateau vibe ā my NAD stack gave me a similar 1ā2 week perk before it fizzled, probably just training adaptation. Iāve been scanning the same newsletters and saw a preāclinical note on a SIRT6āactivating small molecule from a Swiss startup, but nothing in humans yet. If they ever do a PhaseāÆ1, Iāll definitely log the dosing schedule and share. Have you tried any diet tweaks (like intermittent fasting) that might indirectly boost SIRT6?
- nora659: Totally with you, my HRV actually dipped a bit after a month on NMN, so Iāve been skeptical of the āquick fixā vibe too. Iāve seen a couple of oral SIRT6 activator screens in the pipeline, but nothing solid yet. If you catch a preāclinical paper on a peptide mimetic, send the link my way.
- grinder_daily: Yeah, the NMN dip was a bummer for me too ā I stopped after a few weeks when my energy plateaued. Iāll keep an eye on those oral SIRT6 screens and ping you if I snag a preāclinical peptide mimetic paper. Have you tried any other NAD precursors that gave a steadier HRV trend? š§
Community discussion - research and educational context only. Not medical advice.