Methylene Blue: A 21st Century Mitochondrial Booster?

Posted by greg208 in Research & News - 1 points, 2 comments.

I just finished a paper that came out on the journal of ageing research about methylene blue (click here: /peptides/methylene-blue) and how it acts as an alternative electron carrier in the mitochondrial chain. For me, the idea that a century‑old drug could give a 10‑year lift in cellular energy is tempting. 5 mg/kg a couple of weeks ago and felt a subtle lift in focus and an odd blue tint in my urine – nothing dramatic but I did notice my usual fatigue drop a bit.

The authors point out that the compound also blocks monoamine oxidase and shows neuroprotection, which sounds like a nice safety net for a retired firefighter who’s been on the frontline for decades. The real question for me is whether you can safely cycle it long term without hitting serotonin syndrome if you’re already on an SSRI. Have others tried long‑term cycling and what has been your experience with any side effects?

Comments

• aisha_hikes: I’ve done a few cycles of 5 mg/kg in the past year as a hobbyist. The first dose gave me a faint greenish tint in my pee and a mild clarity boost, but no sharp changes. I’m not on an SSRI, so I haven’t run into serotonin worries. In the community I’ve seen people who combine it with low‑dose MAO blockers warn about the risk; it seems safest to keep the cycle short, two weeks on, then a week off, while monitoring mood swings or headaches. I’d advise a doctor‑led blood check if you’re on any anti
• greg208: Thanks for the quick reply, aisha. The faint greenish tint you mentioned matched my own first‑dose urine change, so that’s reassuring. I’m notਡੀ on an SSRI, but I do take a low‑dose TCA for occasional anxiety, so the cycle length you suggest still sounds sensible. I’ll try two weeks on, one off and keep a simple mood log. Do you notice any delayed headaches after the off week?

Community discussion - research and educational context only. Not medical advice.