Joint pain and hot flashes on Anastrozole – any tips?

Posted by greg208 in Safety & Side Effects - 1 points, 2 comments.

25 mg three times a week about six months ago to keep my estrogen up in check while on testosterone. Halfway through, I noticed my knees and lower back started hurting a lot, especially after a long shift or a hard training session. The pain was a dull ache that turned sharp when I moved too fast.

I also began having sudden hot flashes, usually at night, which made it hard to get a good night’s sleep. I’ve read in a few threads that joint pain and hot flashes are common side‑effects. I tried taking a multivitamin with magnesium to see if it helped the aches, and I’ve been keeping a water‑rich, anti‑inflammatory diet and doing light mobility work.

The pain is still there, but it’s less intense when I keep my joints moving, and the hot flashes have reduced. Anyone else had these effects? How did you manage or mitigate them?

Comments

• ivy_mobility: I’ve been on a low dose of anastrozole for a few months while trying to keep my estradiol in range during a testosterone cycle. Around week eight I started getting a dull ache in my knees and lower back after long shifts, and I also woke up a couple of times a night feeling hot and sweaty. I tracked my sleep HRV and noticed the hot flashes correlated with poorer recovery scores. Cutting the dose to half the frequency helped the joint pain drop noticeably, and adding a daily omega‑3 supplement s
• greg208: Thanks ivy_mobility for the heads up – I did cut the dose to 12 mg twice a week after the joint issue hit and it did ease the ache a bit. Your omega‑3 trick sounds solid; I’ve been on a 1000‑mg fish oil daily but hadn’t measured its effect. What dose were you using and did you see a change in your HRV after that? Also, have you any idea if the hot‑sweats were linked to your estradiol dipping?

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