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My 8‑Week CagriSema Trial: Appetite, Nausea, and Plateau Moments

Posted by liam_sleepnerd in Weight Loss & Metabolic - 4 points, 6 comments.

4 mg once a week eight weeks ago after my last tirzepatide run hit a plateau. 4 mg of each is the standard. The first week I felt the expected nausea, just a vague queasy belly and a couple of mild cramps.

By week three the nausea had faded enough that I could eat a normal dinner, but my appetite felt oddly suppressed; I was only hungry at the usual meal times and no more than 150 ml of water in between. 3 % drop. After the week‑six injection I noticed a brief flare of dizziness that lasted about 30 minutes, nothing serious, but worth noting.

5 % of my baseline weight, and my cravings are mild. The injection site is fine except a tiny, transient redness that went away after a day. I’ll keep tracking, but so far the appetite suppression and steady loss feel sustainable.

Comments

  • retired_nomad: I can understand that first few weeks of a new peptide can feel a bit rough. For me, when I started a similar weekly dose, the nausea was mild and went away after a day or two, and I didn’t notice a big change in appetite. I kept my meals light and still felt hungry around the same times I always was. It’s good you’re watching the injection site, small redness is common. I’ve found that staying on top of blood work and keeping a simple log of mood and energy helps make sense of any changes. If
  • data_labrat: I hear you on the nausea being mild, i had it linger a bit longer, like 3–4 days, but it really faded fast. For me the appetite dip stuck around a week or two, then it bounced back. Fwiw, logging{-maybe even just a quick note on your phone} helped me spot the pattern. Did you feel any shift in your energy or mood after the dose?
  • restless_nof1: I hear you. For me the nausea was a little longer, about a week, but still mild. My appetite did dip, about 8–10% in week three, so I kept my meals normal and still ate at my usual times. I log mood, energy and keep routine labs, just like you suggest. How do you track your own changes?
  • liam_sleepnerd: Got it, nausea lasting a whole week is longer than my first‑week blunt queasy feel, but I also saw a flare around week six. I track everything on a spreadsheet: daily weight, Oura HRV, sleep stages, and a simple food log that notes portions and water intake. I also note mood and geldig. How do you log mood and energy?
  • liam_sleepnerd: I did log each dose in a quick phone note, so I saw a pattern too. After the week‑three dose my HRV fv<50% and my energy felt flat for a day or two, no big mood swings, just a mild low‑grade vibe. I didn’t notice a stronger dip, so I think the energy hit is mild. I’ll keep the phone log and see if the pattern shifts when the appetite bounce comes back.
  • liam_sleepnerd: Thanks for the note on how nausea usually eases in a day or two; mine lingered a full week before I could get a normal dinner, but the overall pattern matched. I did notice the brief dizziness after week‑six, has anyone else had that? I’ll keep the blood‑work sprinting and add a simple mood‑energy log as you suggest. Also, how long did the redness stay? I'll check that against my own site reaction.

Community discussion - research and educational context only. Not medical advice.