Reforms, phase 1 of Urolithin A: muscle endurance, energy and mild gut tweak

Posted by greg208 in Longevity & Anti-Aging - 1 points, 4 comments.

Not gonna lie, I just kicked off a week of 750 mg Urolithin A daily and felt a noticeable lift in my leg power after morning runs, about a 15‑ Navigator‑sprint difference. Training loaded at 8‑10 km, I could maintain pace for a minute longer before the fatigue set in. The gut side‑effect was mild, a bit of bloating that eased after the first two doses.

I’m on a low‑dose rapamycin plan, but the two compounds never seemed to clash, at least not yet. Energy during the day feels steadier, especially in the late afternoon when a long shift usually knocks me out. Sleep quality just began to look a tad better, though I recognise it could be a placebo or the training rhythm. I’m still in the honeymoon phase, but I’d love to know if anyone else has paired Urolithin A with low‑dose rapamycin or Metformin and what, if any, differences they’ve seen in endurance or recovery.

Comments

• aspiring_trailrun: I’ve been on 750 mg Urolithin A alongside 1 mg rapamycin for the last month. My leg power felt a touch quicker after a short jog, similar to about a 15‑second boost, but it wasn’t a dramatic jump. The bloating you mentioned is normal – I only felt it for the first couple of days. I haven’t seen any clash with rapamycin; if anything the steady energy helped keep my training sessions a little more consistent in the late afternoon. Have you noticed any subtle shifts in how long you can sustain a h
• greg208: Not gonna lie I was still in the honeymoon week when I saw that 15‑second lift – it was exactly the same bump you mention. I was pushing 8‑10 km and could keep the pace for about a minute longer before the fatigue hit. Recovery feels a bit quicker, but it’s early. Have you noticed any change in how long you can stay at a hard tempo or how fast you bounce back after a tough run?
• tired_ketogen: I’ve been on 750 mg for about two weeks now. My hard‑tempo runs held a touch longer, maybe 20‑30 seconds more before hitting that “yikes” point. Recovery after a 12‑km run felt slightly faster, about 6½ minutes less soreness the next day. Nothing odd with-talkin’ rapamycin. How’s your steady‑energy thing been lately?
• greg208: Thanks for the update, mate. 20‑30 seconds longer is a bit more than my 15‑second jump, so I’m glad it’s adding up. 6½ minutes less soreness sounds a solid sign of quicker recovery – I’ve only been a week, so that’s encouraging. My steady energy’s been good; the late‑afternoon dip is gone, but I’m still rolling through the 9‑10 k runs a touch harder than before. Have you noticed any changes in your sleep since starting rapamycin, or is it still unchanged?

Community discussion - research and educational context only. Not medical advice.