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Trying a Weekly Rapamycin Pulse While Taking NMN and Omega‑3 – My Early Observations

Posted by leah_s in Longevity & Anti-Aging - 3 points, 5 comments.

I started a routine a few weeks ago that blends three things I think help ageing: a weekly 3‑mg dose of rapamycin, a daily 500 mg NMN (taking it with breakfast), and 2 g of combined EPA+DHA omega‑3 in the evening. I’ve been in Sweden, where the sun is short in winter, so I’ve noticed a little more energy in the mornings, especially on days I feel the “rapa‑pulse” kicking in. The NMN has made my mind feel sharper, less foggy, and I’ve slept a bit more soundly after the breakfast dose, probably because it avoids the late‑night flush some people get with IV.

The omega‑3 seems to be keeping my joints a touch smoother – my back feels less stiff after my long walks. I’m still only a month in, and no major side‑effects yet, but I’m curious if anyone else has tried this combo and what they’ve felt about the periodic rapamycin and the daily NMN.

Comments

  • hank_m: Tbh i’ve been doing a similar mix for a couple of months now and the vibes are pretty close to yours, just a bit more subtle on the rapamycin side, i tweak it to a 5‑mg pulse instead of 3 due to the way my gut reacts; i still only do it weekly and never feel the usual nausea nightmare. The NMN feels like a lighter shot of espresso in the morning, i notice less “brain fog” when i hit the keyboard in the early hours, especially when the sun is flat out and i need that extra push to get out the doo
  • leah_s: Thanks for the heads‑up. 5 mg is a bit bigger – I’ll try it, but will keep an eye on any new side effects, especially nausea. How long after the dose does your gut settle? Do you take the rapamycin with a snack or straight after breakfast? That might be why you feel smoother – I’ll adjust my timing too.
  • aspiring_trailrun: Sounds like we’re on the same page. I’ve stuck with 3 mg weekly so far and haven’t felt that dicy կարող with the gut, but I might try bumping to 5 mg to see if it takiⁿs the edge off the early‑morning shimmer. How long does the “rapa‑pulse” feel last for you?
  • leah_s: It’s good you’re staying on 3 mg – I’ve only felt the boost for about four to five mornings after the injection, usually a sharp lift that tapers off by day four. I haven’t had any gut trouble either. If you try 5 mg, watch how long the lift lasts – does it stay stronger or just longer? Would love to hear if the shimmer stays as bright or fades quicker.
  • leah_s: I’ve felt the boost for roughly 18‑20 hours after the weekly dose, so the morning energy kicks in around 6‑8 AM and fades by late afternoon. No gut trouble so far, so I’m hesitant about 5 mg yet, just curious if you notice more stomach upset or a stronger early‑morning glow. Have you tried changing the day of the week for the dose?

Community discussion - research and educational context only. Not medical advice.