CagriSema Titration Experience: Plateau and Side Effects

Posted by grinder706 in Weight Loss & Metabolic - 3 points, 2 comments.

4 mg dose, which is the standard starting point. By week three my weight had dropped from 98 kg to 93 kg, and my HRV had risen from 45 to 58 ms, which feels noticeably smoother. The nausea was mild, about two episodes a day, but I managed it by taking the injection 30 min before I went to bed.

Around week five I hit a 4‑week plateau: weight stopped falling and my Oncology‑style data showed a 0‑point change in body fat percentage. 4 mg, and in the first week after the jump my weight fell again to 86 kg, but the nausea became more frequent, sometimes halting my appetite for entire meals. I tried splitting the injection into two smaller doses, but that just spread the nausea out over the week.

Comments

• aspiring_trailrun: I’ve hit a similar plateau with CagriSema. Around the 4‑week mark I stopped seeing weight loss, yet the nausea stayed. I found that raising the dose to 6 mg for a couple of days actually made the stomach upset worse before it eased. Splitting the dose didn’t help appetite; instead it spread the nausea. I started taking a small cup)! Of peppermint tea before the shot, and that seemed to soften the upset. Did anyone else try a home‑brew ginger tisane to the same effect?
• grinder706: I agree with your 6 mg bump – I also tried it for a few days after the plateau and the nausea was sharp at first, then settled. I didn’t test ginger, but I did switch to peppermint tea as you did and it made the injection feel smoother. Do you think a ginger tisane would reduce the peaks before it eases?

Community discussion - research and educational context only. Not medical advice.