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Tbh my first 4‑week run of FOXO4‑DRI: skin, energy, and post‑cycle fatigue

Posted by hank_m in Longevity & Anti-Aging - 2 points, 3 comments.

Last month I decided to try a 4‑week FOXO4‑DRI cycle, about 10 mg/kg on Monday, Wednesday, Friday, hoping to see a rebound in skin tone and a lift in morning focus. The first week I felt a mild flu‑like buzz in the evenings, a little more tired after dinner but still able to finish my 8‑km run, and my skin looked a touch clearer by the weekend. By week two the inflammation felt a bit less, and I noticed that my usual post‑workout soreness faded faster, maybe the senescent cells were clearing.

The third week I hit a dip – a flu‑ish cold, mild body aches, and my energy dipped in the afternoon, so I cut the dose to two days a week to give my body a break. Week four felt the most balanced: skin glow, steady energy from morning to night, and no major side‑effects. I’m still waiting to see if telomere length changes, but the subjective jump in clarity and the short‑term anti‑inflammatory buzz make me lean toward another cycle down the line, though I’ll keep the post‑cycle rest in mind.

Comments

  • engineer_former: Hey I tried a similar senolytic combo a while I think it was dasatinib+quercetin a while back and got that same mild flu‑ish buzz in the first few days then a dip around week three when I pushed too hard. Cutting back to two doses a week let me settle out and I noticed the skin smoothing and steadier focus you mentioned too. I’m still cautious about long‑term telomere claims until I see some blood work but the short term anti‑inflammatory vibe feels real for me. Would love to hear if you kept a
  • hank_m: I didn't log any markers, just felt the buzz, the dip, and the skin glow, but would love to add a CRP or CBC next round to see what the numbers show, especially since you’re seeing that same pattern, and a gentle taper did help me resolve the flu‑ish phase, so I’d try a two‑day taper next time too.
  • hank_m: Tbh i never did a full panel during FOXO4‑DRI, just a quick CBC before and after the cycle, nothing fancy, and CRP was fine – the values stayed in the normal range, so it felt safe, but i wish i’d tracked IL‑6 or ferritin next time, might have shown the inflammation dip more clearly, but a gentle taper seems smart, i’ll try that next round.

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